Subtelomeric heterochromatin formation

Across TCGA patient cohorts, RNA activity of the Subtelomeric heterochromatin formation pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NUF2, FANCB, and XRCC2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Subtelomeric heterochromatin formation activity versus NUF2 in HNSC (Pearson r = 0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	NUF2 →	+0.964	+0.434	<.001	.001	3	8
GBM	FANCB →	+0.887	+0.827	<.001	<.001	3	8
GBM	XRCC2 →	+1.282	+0.862	<.001	<.001	3	8
LSCC	KIF4A →	+0.808	+1.037	<.001	<.001	3	8
LSCC	CDC25C →	+0.815	+1.070	<.001	<.001	3	8
LSCC	SPAG5 →	+1.040	+1.062	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031509 vs NUF2 — HNSC

Explore this scatter interactively →