Subtelomeric heterochromatin formation

Across TCGA cell cohorts, RNA activity of the Subtelomeric heterochromatin formation pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PXDC1, NABP1, and NNMT, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PXDC1 grouped by Subtelomeric heterochromatin formation-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	PXDC1 →	-2.528	-1.281	.003	.006	3	6
CNS	NABP1 →	-1.147	-0.872	.007	.006	2	7
LUNG_NSCLC_LUSC	NNMT →	-5.608	-1.768	<.001	<.001	3	5
LUNG_NSCLC_LUSC	CBX2 →	+1.596	+1.357	.003	<.001	3	5
KIDNEY	TTC21A →	-0.996	-1.313	.003	.001	3	5
SOFT_TISSUE	KREMEN2 →	+3.273	+1.635	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PXDC1 by Subtelomeric heterochromatin formation activity — SOFT_TISSUE

Explore this box plot interactively →