Subtelomeric heterochromatin formation

Across TCGA cell cohorts, RNA activity of the Subtelomeric heterochromatin formation pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DOT1L, USP37, and SUGP2, each associated with the pathway in up to 19 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Subtelomeric heterochromatin formation activity versus DOT1L in SOFT_TISSUE (Pearson r = 0.85).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	DOT1L →	+1.396	+0.131	<.001	<.001	3	19
BLOOD_Myeloma	USP37 →	+1.168	+0.101	<.001	<.001	3	19
UPPER_AERODIGESTIVE_TRACT	SUGP2 →	+0.987	+0.078	<.001	.001	3	19
LARGE_INTESTINE	PIAS4 →	+1.018	+0.110	<.001	<.001	3	18
BONE	CACTIN →	+1.045	+0.135	<.001	<.001	3	18
STOMACH	CEP164 →	+1.235	+0.119	<.001	.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031509 vs DOT1L — SOFT_TISSUE

Explore this scatter interactively →