Pericentric heterochromatin formation

Across TCGA patient cohorts, RNA activity of the Pericentric heterochromatin formation pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PARP2, CHAF1B, and RFC2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pericentric heterochromatin formation activity versus PARP2 in LSCC (Pearson r = 0.45).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PARP2 →	+0.389	+0.057	<.001	<.001	3	9
GBM	CHAF1B →	+0.726	+0.098	<.001	<.001	3	8
GBM	RFC2 →	+0.412	+0.095	<.001	<.001	3	8
OV	TIMELESS_S1173 →	+1.276	+0.060	<.001	<.001	3	8
UCEC	KIF2C →	+0.764	+0.070	<.001	<.001	3	8
GBM	TMPO →	+0.348	+0.087	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031508 vs PARP2 — LSCC

Explore this scatter interactively →