Pericentric heterochromatin formation

Across TCGA cell cohorts, RNA activity of the Pericentric heterochromatin formation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TEX264, NEIL3, and HIVEP2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TEX264 grouped by Pericentric heterochromatin formation-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TEX264 →	-0.762	-1.259	.009	.001	3	4
SKIN	NEIL3 →	+0.447	+0.875	<.001	.002	3	4
BLOOD_Leukemia	HIVEP2 →	+1.454	+1.140	.005	.003	3	4
URINARY_TRACT	GSTCD →	+0.853	+0.412	<.001	.009	3	4
BLOOD_Leukemia	MEF2C →	+2.835	+1.148	<.001	<.001	3	4
BLOOD_Leukemia	PIGB →	-1.013	-1.442	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TEX264 by Pericentric heterochromatin formation activity — BLOOD_Leukemia

Explore this box plot interactively →