Pericentric heterochromatin formation

Across TCGA cell cohorts, RNA activity of the Pericentric heterochromatin formation pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CENPV, FAM171A2, and TOP3A, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pericentric heterochromatin formation activity versus CENPV in BREAST (Pearson r = 0.80).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	CENPV →	+3.906	+1.927	<.001	<.001	3	9
BLOOD_Leukemia	FAM171A2 →	+0.982	+0.853	.001	<.001	3	8
BREAST	TOP3A →	+1.162	+1.643	.002	.005	3	7
BLOOD_Leukemia	MEX3A →	+1.242	+1.133	.006	.002	3	6
BLOOD_Leukemia	TIGD3 →	+0.550	+0.958	.002	.002	3	6
BLOOD_Leukemia	CNIH2 →	+1.265	+1.267	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031508 vs CENPV — BREAST

Explore this scatter interactively →