Protein-containing complex localization

Across TCGA patient cohorts, RNA activity of the Protein-containing complex localization pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WDR6, CCDC93, and LINC02604, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein-containing complex localization activity versus WDR6 in BRCA (Pearson r = 0.04).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	WDR6 →	+1.633	+0.319	.005	<.001	3	3
COAD	CCDC93 →	+0.449	+0.139	.008	<.001	3	3
COAD	LINC02604 →	+0.768	+0.132	<.001	<.001	3	3
BRCA	NINL →	+1.872	+0.319	.001	<.001	3	2
BRCA	RBFA →	+0.885	+0.319	.005	<.001	3	2
BRCA	CCDC61 →	+1.050	+0.319	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031503 vs WDR6 — BRCA

Explore this scatter interactively →