Protein-containing complex localization

Across TCGA patient cohorts, RNA activity of the Protein-containing complex localization pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TAOK2_S486, WIPI2_S413, and RERE, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein-containing complex localization activity versus TAOK2_S486 in OV (Pearson r = -0.16).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	TAOK2_S486 →	-0.865	-0.182	<.001	<.001	3	2
OV	WIPI2_S413 →	+0.864	+0.193	.005	.003	3	2
COAD	RERE →	+0.703	+0.186	<.001	<.001	3	1
COAD	REV3L_S2147 →	-0.655	-0.273	<.001	<.001	3	1
COAD	RHOT2_S325 →	+0.622	+0.240	.001	.003	3	1
COAD	RIN2_S484 →	+0.490	+0.194	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031503 vs TAOK2_S486 — OV

Explore this scatter interactively →