Nuclear membrane reassembly

Across TCGA patient cohorts, RNA activity of the Nuclear membrane reassembly pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are C1S, MAP1A_S1776, and MAP1B_S1427, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nuclear membrane reassembly activity versus C1S in BRCA (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	C1S →	+0.595	+0.037	<.001	<.001	3	5
CCRCC	MAP1A_S1776 →	+0.464	+0.048	<.001	<.001	3	5
CCRCC	MAP1B_S1427 →	+0.634	+0.026	<.001	<.001	3	5
CCRCC	MMP14 →	+0.343	+0.037	<.001	<.001	3	5
GBM	DNM1 →	+0.554	+0.048	.003	.003	2	6
OV	EIF3A →	-0.169	-0.032	.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031468 vs C1S — BRCA

Explore this scatter interactively →