Nuclear membrane reassembly

Across TCGA patient cohorts, RNA activity of the Nuclear membrane reassembly pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACCS, ARGLU1, and H1-10, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nuclear membrane reassembly activity versus ACCS in BRCA (Pearson r = -0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ACCS →	-0.490	-0.103	.001	<.001	3	3
CCRCC	ARGLU1 →	-0.333	-0.191	<.001	.002	3	3
HNSC	H1-10 →	-0.713	-0.125	.006	.003	3	3
CCRCC	RNA5SP210 →	-0.479	-0.160	.002	.002	3	3
CCRCC	LINC01919 →	-0.151	-0.149	.003	.008	3	3
OV	SNHG20 →	-0.396	-0.140	.009	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031468 vs ACCS — BRCA

Explore this scatter interactively →