Nuclear membrane reassembly

Across TCGA cell cohorts, RNA activity of the Nuclear membrane reassembly pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF623, PER3, and SAAL1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF623 grouped by Nuclear membrane reassembly-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ZNF623 →	+1.027	+0.326	.002	.004	3	4
SKIN	PER3 →	-1.219	-0.232	<.001	<.001	3	4
LUNG_SCLC	SAAL1 →	+1.066	+0.356	<.001	<.001	3	4
BLOOD_Leukemia	GTF3C3 →	+0.814	+0.271	.003	.001	3	4
LUNG_SCLC	CNOT6L →	+0.872	+0.261	<.001	<.001	3	4
LUNG_SCLC	AGO2 →	+0.704	+0.259	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF623 by Nuclear membrane reassembly activity — LUNG_SCLC

Explore this box plot interactively →