Nuclear membrane reassembly

Across TCGA cell cohorts, RNA activity of the Nuclear membrane reassembly pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are POLR3K, SLAIN1, and NUP93, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nuclear membrane reassembly activity versus POLR3K in URINARY_TRACT (Pearson r = 0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	POLR3K →	+1.023	+0.381	.004	.002	3	7
KIDNEY	SLAIN1 →	+1.851	+0.361	.008	.003	3	6
BLOOD_Lymphoma	NUP93 →	+0.713	+0.233	.002	.006	3	6
LUNG_SCLC	ILF3 →	+0.594	+0.210	<.001	<.001	3	6
LUNG_SCLC	ZNF397 →	+1.016	+0.213	<.001	<.001	3	6
BLOOD_Leukemia	IMMP1L →	+0.942	+0.157	.009	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031468 vs POLR3K — URINARY_TRACT

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