Positive regulation of mRNA 3'-end processing

Across TCGA patient cohorts, RNA activity of the Positive regulation of mRNA 3'-end processing pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GATAD2B, IPO9, and RPRD2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of mRNA 3'-end processing activity versus GATAD2B in HNSC (Pearson r = 0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	GATAD2B →	+0.221	+0.053	<.001	.002	3	7
LSCC	IPO9 →	+0.320	+0.062	<.001	<.001	3	6
HNSC	RPRD2 →	+0.282	+0.076	<.001	<.001	3	6
UCEC	POGZ →	+0.279	+0.080	<.001	<.001	3	6
UCEC	RO60 →	+0.204	+0.061	.007	.002	3	6
UCEC	AIDA →	+0.405	+0.102	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031442 vs GATAD2B — HNSC

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