Positive regulation of mRNA 3'-end processing

Across TCGA patient cohorts, RNA activity of the Positive regulation of mRNA 3'-end processing pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CENPH, BRI3BP, and NUP210, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of mRNA 3'-end processing activity versus CENPH in OV (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CENPH →	+0.745	+0.817	.002	.002	3	5
HNSC	BRI3BP →	+0.446	+0.100	<.001	.005	3	4
GBM	NUP210 →	+0.497	+0.262	<.001	<.001	3	4
GBM	MKI67 →	+0.749	+0.146	<.001	.003	3	4
GBM	SKA1 →	+0.650	+0.175	<.001	<.001	3	4
GBM	FAM111B →	+0.870	+0.247	.006	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031442 vs CENPH — OV

Explore this scatter interactively →