Positive regulation of mRNA 3'-end processing

Across TCGA cell cohorts, RNA activity of the Positive regulation of mRNA 3'-end processing pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NCBP1, POLE3, and UBQLN1, each associated with the pathway in up to 20 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of mRNA 3'-end processing activity versus NCBP1 in BONE (Pearson r = 0.68).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	NCBP1 →	+0.875	+0.148	<.001	<.001	3	20
BLOOD_Lymphoma	POLE3 →	+1.519	+0.110	<.001	<.001	3	20
PANCREAS	UBQLN1 →	+0.995	+0.144	<.001	<.001	3	19
SOFT_TISSUE	RC3H2 →	+0.767	+0.118	.001	<.001	3	18
BLOOD_Lymphoma	FUBP3 →	+0.753	+0.080	<.001	<.001	3	18
BLOOD_Myeloma	SET →	+0.895	+0.089	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031442 vs NCBP1 — BONE

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