Positive regulation of mRNA 3'-end processing

Across TCGA cell cohorts, RNA activity of the Positive regulation of mRNA 3'-end processing pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SKP2, SNRPA, and MEX3A, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of mRNA 3'-end processing activity versus SKP2 in BLOOD_Leukemia (Pearson r = 0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SKP2 →	+0.853	+0.914	.001	<.001	3	7
BREAST	SNRPA →	+0.481	+1.001	.003	<.001	3	6
BLOOD_Myeloma	MEX3A →	+1.757	+1.745	<.001	<.001	3	6
BREAST	KHDRBS1 →	+0.565	+0.969	<.001	<.001	3	5
SKIN	HPRT1 →	+0.656	+0.847	.003	.009	3	5
BREAST	LBR →	+1.080	+1.083	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031442 vs SKP2 — BLOOD_Leukemia

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