Regulation of mRNA 3'-end processing

Across TCGA patient cohorts, RNA activity of the Regulation of mRNA 3'-end processing pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are IPO9, MTA1, and PARP4, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of mRNA 3'-end processing activity versus IPO9 in GBM (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	IPO9 →	+0.327	+0.080	<.001	<.001	3	8
GBM	MTA1 →	+0.409	+0.079	<.001	<.001	3	7
GBM	PARP4 →	-0.397	-0.053	.003	.005	3	7
COAD	PPP4R3A →	+0.266	+0.054	<.001	<.001	3	7
LSCC	RPRD2 →	+0.394	+0.067	<.001	<.001	3	7
LSCC	UBR7 →	+0.395	+0.045	.001	.004	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031440 vs IPO9 — GBM

Explore this scatter interactively →