Regulation of mRNA 3'-end processing

Across TCGA cell cohorts, RNA activity of the Regulation of mRNA 3'-end processing pathway is significantly associated with the shRNA dependency of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF800, ZNF652, and PCGF2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF800 grouped by Regulation of mRNA 3'-end processing-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ZNF800 →	+0.218	+0.121	.009	.003	3	6
SOFT_TISSUE	ZNF652 →	+0.123	+0.141	.007	.003	3	5
STOMACH	PCGF2 →	+0.173	+0.112	.003	.001	3	5
OVARY	LIFR →	+0.319	+0.219	.003	.005	3	4
UPPER_AERODIGESTIVE_TRACT	KDM4B →	+0.141	+0.126	<.001	.002	3	4
OVARY	KIR2DS4 →	+0.237	+0.191	.006	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF800 by Regulation of mRNA 3'-end processing activity — STOMACH

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