Regulation of mRNA 3'-end processing

Across TCGA cell cohorts, RNA activity of the Regulation of mRNA 3'-end processing pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NCBP1, CLP1, and TEX10, each associated with the pathway in up to 18 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of mRNA 3'-end processing activity versus NCBP1 in BLOOD_Myeloma (Pearson r = 0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	NCBP1 →	+0.847	+0.092	<.001	.002	3	17
LIVER	CLP1 →	+0.866	+0.089	.009	.004	2	18
PANCREAS	TEX10 →	+1.217	+0.116	<.001	<.001	3	15
BLOOD_Myeloma	SET →	+1.216	+0.123	<.001	<.001	3	14
BLOOD_Myeloma	SMC2 →	+1.640	+0.109	<.001	<.001	3	14
PANCREAS	CDCA5 →	+1.480	+0.113	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031440 vs NCBP1 — BLOOD_Myeloma

Explore this scatter interactively →