Keratinization

Across TCGA patient cohorts, RNA activity of the Keratinization pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PPL, KRT17, and KRT80, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Keratinization activity versus PPL in LSCC (Pearson r = 0.46).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PPL →	+0.849	+0.181	<.001	<.001	3	9
LSCC	KRT17 →	+1.590	+0.164	<.001	<.001	3	9
LSCC	KRT80 →	+1.187	+0.157	<.001	<.001	3	8
OV	TRIM29 →	+1.055	+0.062	<.001	<.001	3	7
LSCC	AHNAK2 →	+0.725	+0.112	<.001	<.001	3	7
LSCC	SFN →	+0.883	+0.174	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031424 vs PPL — LSCC

Explore this scatter interactively →