Keratinization

Across TCGA patient cohorts, RNA activity of the Keratinization pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KRT5, KRT17, and TRIM29, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Keratinization activity versus KRT5 in LSCC (Pearson r = 0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	KRT5 →	+2.898	+0.843	<.001	<.001	3	8
BRCA	KRT17 →	+2.552	+0.972	<.001	<.001	3	7
BRCA	TRIM29 →	+1.741	+0.930	<.001	<.001	3	7
LSCC	KRT6A →	+3.152	+0.828	<.001	<.001	3	7
BRCA	KRT80 →	+1.299	+1.088	<.001	<.001	3	7
LSCC	KRT16 →	+2.832	+0.766	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031424 vs KRT5 — LSCC

Explore this scatter interactively →