Keratinization

Across TCGA cell cohorts, RNA activity of the Keratinization pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PEX10, KANSL1, and SSH1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PEX10 grouped by Keratinization-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	PEX10 →	-0.810	-0.862	.003	.006	3	5
BREAST	KANSL1 →	-0.627	-0.849	.005	.004	3	5
BREAST	SSH1 →	-0.803	-1.113	.004	<.001	3	5
LUNG_SCLC	FNIP1 →	-0.627	-1.106	.002	.008	3	4
OVARY	SPDYE3 →	-0.569	-0.677	<.001	.006	3	4
URINARY_TRACT	MAP3K10 →	-1.231	-1.456	.004	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PEX10 by Keratinization activity — SOFT_TISSUE

Explore this box plot interactively →