Keratinization

Across TCGA cell cohorts, RNA activity of the Keratinization pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PDXP, STRBP, and RAET1L, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Keratinization activity versus PDXP in URINARY_TRACT (Pearson r = -0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	PDXP →	-1.621	-0.494	.008	.001	3	6
LUNG_NSCLC_LUSC	STRBP →	-1.069	-0.540	.004	<.001	3	6
STOMACH	RAET1L →	+1.518	+0.442	.007	.002	3	6
URINARY_TRACT	TMEM40 →	+5.895	+0.709	<.001	.006	3	6
OESOPHAGUS	S100A2 →	+3.022	+0.459	<.001	<.001	3	5
URINARY_TRACT	GPR87 →	+4.046	+0.556	.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031424 vs PDXP — URINARY_TRACT

Explore this scatter interactively →