Positive regulation of protein ubiquitination

Across TCGA patient cohorts, RNA activity of the Positive regulation of protein ubiquitination pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACRV1, PIF1, and FOXM1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of protein ubiquitination activity versus ACRV1 in LUAD (Pearson r = 0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	ACRV1 →	+0.374	+0.130	.002	.001	3	4
BRCA	PIF1 →	+0.686	+0.109	.004	.007	3	4
BRCA	FOXM1 →	+1.099	+0.151	<.001	.001	3	4
BRCA	EDA2R →	-0.637	-0.117	<.001	<.001	3	4
CCRCC	PSMB2 →	+0.304	+0.222	.001	<.001	3	3
BRCA	PRR15L →	-0.949	-0.102	.003	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031398 vs ACRV1 — LUAD

Explore this scatter interactively →