Positive regulation of protein ubiquitination

Across TCGA cell cohorts, RNA activity of the Positive regulation of protein ubiquitination pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are XYLT2, ADPRS, and EVA1A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, XYLT2 grouped by Positive regulation of protein ubiquitination-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	XYLT2 →	-0.829	-0.151	<.001	.002	3	5
LUNG_SCLC	ADPRS →	+0.513	+0.187	.005	.001	3	5
UPPER_AERODIGESTIVE_TRACT	EVA1A →	-2.860	-0.278	.002	.008	3	4
BONE	TBC1D9B →	-0.750	-0.125	.001	.001	3	4
LUNG_NSCLC_LUSC	VEGFB →	-0.764	-0.163	.001	.009	3	4
SKIN	NSUN6 →	+0.667	+0.185	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

XYLT2 by Positive regulation of protein ubiquitination activity — CNS

Explore this box plot interactively →