Positive regulation of protein ubiquitination

Across TCGA cell cohorts, RNA activity of the Positive regulation of protein ubiquitination pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADNP, NUMB, and GBA, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of protein ubiquitination activity versus ADNP in KIDNEY (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	ADNP →	+0.703	+0.171	<.001	<.001	3	5
BLOOD_Myeloma	NUMB →	+1.216	+0.184	.005	<.001	3	5
BONE	GBA →	-1.747	-0.504	.006	.002	3	4
BONE	SF3A2 →	+0.623	+0.374	.003	.004	2	5
BONE	LIF →	-3.974	-0.486	.001	.003	3	4
LUNG_SCLC	RPRD1A →	+0.560	+0.183	.007	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031398 vs ADNP — KIDNEY

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