Negative regulation of protein ubiquitination

Across TCGA patient cohorts, RNA activity of the Negative regulation of protein ubiquitination pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PTBP2, MAP2_S1155, and MX2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of protein ubiquitination activity versus PTBP2 in GBM (Pearson r = 0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PTBP2 →	+0.623	+0.041	.002	<.001	3	7
LSCC	MAP2_S1155 →	+1.740	+0.043	<.001	.001	3	6
LUAD	MX2 →	+0.447	+0.025	.001	.001	3	6
COAD	RPL5 →	-0.146	-0.025	.001	<.001	3	6
GBM	EEF2 →	-0.258	-0.051	<.001	<.001	3	6
LSCC	MAP1B_S992 →	+0.804	+0.029	.004	.002	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031397 vs PTBP2 — GBM

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