Negative regulation of protein ubiquitination

Across TCGA patient cohorts, RNA activity of the Negative regulation of protein ubiquitination pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MCF2L, C1orf115, and PARM1-AS1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of protein ubiquitination activity versus MCF2L in CCRCC (Pearson r = -0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	MCF2L →	-0.714	-0.239	<.001	<.001	3	5
CCRCC	C1orf115 →	-0.782	-0.166	.003	.007	2	6
GBM	PARM1-AS1 →	-0.311	-0.089	.008	.002	2	6
LSCC	OAS2 →	+0.790	+0.099	<.001	<.001	3	5
CCRCC	LIMK1 →	+0.724	+0.263	<.001	<.001	3	5
CCRCC	CENPV →	-0.487	-0.209	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031397 vs MCF2L — CCRCC

Explore this scatter interactively →