Negative regulation of protein ubiquitination

Across TCGA cell cohorts, RNA activity of the Negative regulation of protein ubiquitination pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RLIM, CENPI, and RC3H2, each associated with the pathway in up to 16 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of protein ubiquitination activity versus RLIM in OVARY (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	RLIM →	+0.885	+0.084	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	CENPI →	+1.392	+0.062	<.001	<.001	3	16
LARGE_INTESTINE	RC3H2 →	+0.630	+0.050	.001	.001	3	15
BLOOD_Lymphoma	KIF2A →	+1.242	+0.071	<.001	<.001	3	14
BLOOD_Lymphoma	FUBP3 →	+1.028	+0.070	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	TAF1 →	+1.225	+0.051	<.001	.008	2	15

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031397 vs RLIM — OVARY

Explore this scatter interactively →