Negative regulation of protein ubiquitination

Across TCGA cell cohorts, RNA activity of the Negative regulation of protein ubiquitination pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BAZ2A, SLC20A2, and FGF14, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of protein ubiquitination activity versus BAZ2A in BLOOD_Myeloma (Pearson r = -0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	BAZ2A →	-0.818	-0.182	.001	.004	3	5
SOFT_TISSUE	SLC20A2 →	+1.213	+0.178	.004	<.001	3	5
LUNG_NSCLC_LUAD	FGF14 →	+0.117	+0.157	.003	.009	3	5
LUNG_NSCLC_LUSC	BICD1 →	+1.208	+0.285	.001	.008	3	5
LUNG_NSCLC_LUAD	PIP4P2 →	+1.577	+0.196	<.001	.001	3	5
LIVER	HECW1 →	+2.581	+0.256	<.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031397 vs BAZ2A — BLOOD_Myeloma

Explore this scatter interactively →