Regulation of protein ubiquitination

Across TCGA patient cohorts, RNA activity of the Regulation of protein ubiquitination pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are A4GNT, CCNL1, and SNORA20, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of protein ubiquitination activity versus A4GNT in COAD (Pearson r = 0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	A4GNT →	+0.152	+0.119	.009	<.001	3	2
COAD	CCNL1 →	+0.489	+0.144	.008	.007	3	2
COAD	SNORA20 →	+0.879	+0.169	.002	<.001	3	2
COAD	MTND5P25 →	+0.284	+0.161	.004	.002	3	2
COAD	FMO7P →	+0.248	+0.133	.006	.003	3	2
COAD	LINC02595 →	+0.536	+0.128	.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031396 vs A4GNT — COAD

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