Regulation of protein ubiquitination

Across TCGA cell cohorts, RNA activity of the Regulation of protein ubiquitination pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATP5MC2, HCAR1, and SF3A2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of protein ubiquitination activity versus ATP5MC2 in LUNG_NSCLC_LUSC (Pearson r = -0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	ATP5MC2 →	-0.571	-0.218	.001	.008	3	4
LUNG_NSCLC_LUSC	HCAR1 →	+2.350	+0.342	.002	<.001	3	4
KIDNEY	SF3A2 →	+1.131	+0.138	.002	.003	2	5
LUNG_SCLC	HMGCS1 →	+1.551	+0.132	<.001	.001	3	4
LUNG_SCLC	XRN1 →	+0.550	+0.109	.001	<.001	3	4
LUNG_SCLC	RPS27A →	-0.700	-0.132	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031396 vs ATP5MC2 — LUNG_NSCLC_LUSC

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