Positive regulation of prostaglandin biosynthetic process

Across TCGA patient cohorts, RNA activity of the Positive regulation of prostaglandin biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LGG cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANXA1, TMEM97, and NCOA5, each associated with the pathway in up to 28 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of prostaglandin biosynthetic process activity versus ANXA1 in LGG (Pearson r = 0.04).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LGG	ANXA1 →	+2.383	+0.166	<.001	<.001	3	28
ACC	TMEM97 →	-1.879	-0.093	.004	.005	1	20
DLBC	NCOA5 →	-0.636	-0.076	.001	.002	2	19
ESCA	PATZ1 →	-0.734	-0.106	<.001	<.001	3	17
ESCA	UBTF →	-0.341	-0.075	<.001	.001	3	17
THYM	CHD6 →	-0.902	-0.076	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031394 vs ANXA1 — LGG

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