Positive regulation of prostaglandin biosynthetic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of prostaglandin biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PDGFA, C1orf109, and CD109, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PDGFA grouped by Positive regulation of prostaglandin biosynthetic process-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PDGFA →	-1.759	-0.961	.004	<.001	3	4
LIVER	C1orf109 →	+0.640	+1.866	.009	<.001	3	4
OESOPHAGUS	CD109 →	+0.852	+0.829	<.001	.004	3	4
STOMACH	TMED8 →	+0.683	+1.131	.003	.003	3	3
PANCREAS	DPH2 →	+0.973	+1.077	.001	.002	2	4
STOMACH	SORD →	+0.662	+0.924	.003	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PDGFA by Positive regulation of prostaglandin biosynthetic process activity — LARGE_INTESTINE

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