Positive regulation of prostaglandin biosynthetic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of prostaglandin biosynthetic process pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BATF, C19orf53, and UBE2G2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BATF grouped by Positive regulation of prostaglandin biosynthetic process-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	BATF →	-0.210	-0.170	.003	.002	3	4
BLOOD_Myeloma	C19orf53 →	-0.165	-0.552	<.001	.007	3	3
KIDNEY	UBE2G2 →	-0.214	-0.262	<.001	.002	3	3
KIDNEY	GBP7 →	+0.435	+0.427	.002	.002	3	3
URINARY_TRACT	GPR20 →	+0.108	+0.166	.003	.008	3	3
URINARY_TRACT	DGKQ →	-0.175	-0.188	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BATF by Positive regulation of prostaglandin biosynthetic process activity — BLOOD_Leukemia

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