Positive regulation of prostaglandin biosynthetic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of prostaglandin biosynthetic process pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MUCL3, ARHGAP28, and PALMD, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MUCL3 grouped by Positive regulation of prostaglandin biosynthetic process-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	MUCL3 →	+0.175	+2.526	.004	.008	3	1
LUNG_NSCLC_LUAD	ARHGAP28 →	-0.250	-2.526	.006	.008	2	1
LUNG_NSCLC_LUAD	PALMD →	+0.245	+2.139	<.001	.002	2	1
LUNG_NSCLC_LUAD	FAM185BP →	+0.348	+2.139	.005	.002	2	1
LUNG_NSCLC_LUAD	RPS28 →	+0.150	+2.139	.002	.002	2	1
LUNG_NSCLC_LUAD	RTL5 →	+0.270	+2.283	.008	.006	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MUCL3 by Positive regulation of prostaglandin biosynthetic process activity — LUNG_NSCLC_LUAD

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