Positive regulation of prostaglandin biosynthetic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of prostaglandin biosynthetic process pathway is significantly associated with the drug response of multiple features, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are Docetaxel, Palbociclib, and Pyridostatin, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, Docetaxel grouped by Positive regulation of prostaglandin biosynthetic process-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	Docetaxel →	-1.218	-1.014	.018	.047	3	1
LUNG_NSCLC_LUAD	Palbociclib →	-0.641	-1.066	.035	.035	3	1
SKIN	Pyridostatin →	+0.943	+0.263	.009	.048	3	1
SKIN	KIN001-260 →	+0.424	+0.131	.030	.005	3	1
LUNG_NSCLC_LUAD	Dactinomycin →	-0.975	-2.057	.030	.006	2	1
LUNG_NSCLC_LUAD	Romidepsin →	-0.624	-2.057	.023	.006	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Docetaxel by Positive regulation of prostaglandin biosynthetic process activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →