Negative regulation of prostaglandin biosynthetic process

pathway activity — cross-omics
GO:0031393Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Negative regulation of prostaglandin biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GPALPP1, RASAL3_S51, and NEK1_S837, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
COADGPALPP1 →+0.326+0.046.003.00434
LUADRASAL3_S51 →-0.345-0.081.001.00325
UCECNEK1_S837 →-0.455-0.141.003.00434
GBMKMT2A_T3028 →+0.516+0.147<.001<.00134
PDACCYBA_T147 →-0.825-0.115<.001<.00133
CCRCCFMN2_S482 →+0.506+0.189.009.00533
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration