N-terminal protein amino acid modification

Across TCGA patient cohorts, RNA activity of the N-terminal protein amino acid modification pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYLK, ARHGDIB, and SCAT2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, N-terminal protein amino acid modification activity versus MYLK in PDAC (Pearson r = -0.03).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	MYLK →	-0.308	-0.121	.003	<.001	3	5
LSCC	ARHGDIB →	-0.605	-0.162	<.001	.001	3	4
LSCC	SCAT2 →	+0.693	+0.182	<.001	.001	3	4
PDAC	LAMB2 →	-0.450	-0.203	<.001	<.001	3	4
LSCC	MIR145 →	-0.694	-0.157	.001	.005	3	4
OV	ALOX5AP →	-0.977	-0.293	.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031365 vs MYLK — PDAC

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