Negative regulation of cell projection organization

Across TCGA patient cohorts, RNA activity of the Negative regulation of cell projection organization pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MAP1A, PCOLCE, and MAP1A_S2106, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cell projection organization activity versus MAP1A in LSCC (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MAP1A →	+0.601	+0.030	<.001	.001	3	9
LSCC	PCOLCE →	+0.576	+0.030	<.001	.001	3	8
LSCC	MAP1A_S2106 →	+0.595	+0.027	.003	.001	3	8
LSCC	MAP1B →	+0.893	+0.026	.001	.003	3	8
OV	C1S →	+0.589	+0.039	<.001	<.001	3	7
BRCA	COL1A2 →	+0.510	+0.019	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031345 vs MAP1A — LSCC

Explore this scatter interactively →