Negative regulation of cell projection organization

Across TCGA cell cohorts, RNA activity of the Negative regulation of cell projection organization pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SFXN4, NCEH1, and ACOT8, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cell projection organization activity versus SFXN4 in LARGE_INTESTINE (Pearson r = -0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SFXN4 →	-0.966	-0.197	.001	.002	3	7
PANCREAS	NCEH1 →	+2.482	+0.316	<.001	<.001	3	6
URINARY_TRACT	ACOT8 →	+0.802	+0.412	.008	.004	3	5
URINARY_TRACT	ARPC5 →	+1.062	+0.524	.001	<.001	3	5
CNS	CRYBG1 →	+2.378	+0.252	<.001	<.001	3	5
CNS	CCDC71L →	+1.560	+0.216	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031345 vs SFXN4 — LARGE_INTESTINE

Explore this scatter interactively →