Negative regulation of cell killing

Across TCGA patient cohorts, RNA activity of the Negative regulation of cell killing pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FASLG, CD72, and HLA-F, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cell killing activity versus FASLG in HNSC (Pearson r = 0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	FASLG →	+0.672	+0.172	.002	.001	3	9
GBM	CD72 →	+0.646	+0.266	<.001	<.001	3	9
HNSC	HLA-F →	+0.851	+0.227	.001	<.001	3	9
BRCA	BTN3A3 →	+1.025	+0.247	<.001	<.001	3	8
LSCC	GBP5 →	+1.235	+0.449	<.001	<.001	3	8
GBM	GBP2 →	+0.789	+0.188	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031342 vs FASLG — HNSC

Explore this scatter interactively →