Negative regulation of cell killing

Across TCGA cell cohorts, RNA activity of the Negative regulation of cell killing pathway is significantly associated with the shRNA dependency of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EHMT1, PLK2, and PLIN1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EHMT1 grouped by Negative regulation of cell killing-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	EHMT1 →	-0.206	-0.160	.006	.007	3	5
LUNG_SCLC	PLK2 →	-0.173	-0.226	.008	.004	3	4
LUNG_SCLC	PLIN1 →	-0.328	-0.294	.001	<.001	3	4
BLOOD_Leukemia	TAMALIN →	+0.139	+0.126	.008	.007	2	5
BREAST	NACA →	+0.320	+0.138	.006	.001	3	4
LIVER	PPP1R12A →	+0.333	+0.207	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EHMT1 by Negative regulation of cell killing activity — STOMACH

Explore this box plot interactively →