Negative regulation of cell killing

Across TCGA cell cohorts, RNA activity of the Negative regulation of cell killing pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLIN3, IL6ST, and ITGB1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cell killing activity versus PLIN3 in LUNG_SCLC (Pearson r = 0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PLIN3 →	+1.889	+0.327	.002	.001	3	10
STOMACH	IL6ST →	+2.127	+0.413	.001	<.001	3	8
BONE	ITGB1 →	+1.754	+0.461	.009	.008	2	8
SKIN	CCN1 →	+2.882	+0.218	.004	.008	3	7
BONE	MYOF →	+5.962	+0.574	<.001	.002	3	7
BONE	AXL →	+6.146	+0.413	<.001	.009	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031342 vs PLIN3 — LUNG_SCLC

Explore this scatter interactively →