Regulation of cell killing

Across TCGA patient cohorts, RNA activity of the Regulation of cell killing pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DNAJC5B, FYB1, and BIN2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cell killing activity versus DNAJC5B in LSCC (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	DNAJC5B →	+0.529	+0.295	<.001	<.001	3	9
HNSC	FYB1 →	+1.114	+0.315	<.001	<.001	3	9
LSCC	BIN2 →	+0.856	+0.349	<.001	<.001	3	9
HNSC	ARHGAP9 →	+0.816	+0.302	<.001	<.001	3	9
HNSC	IFNG →	+1.137	+0.343	<.001	<.001	3	8
HNSC	CD53 →	+0.960	+0.301	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031341 vs DNAJC5B — LSCC

Explore this scatter interactively →