Positive regulation of vesicle fusion

Across TCGA patient cohorts, RNA activity of the Positive regulation of vesicle fusion pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SYNPO_S685, RPL5, and BAZ1B, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of vesicle fusion activity versus SYNPO_S685 in PDAC (Pearson r = 0.05).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	SYNPO_S685 →	-0.651	-0.036	.001	.005	3	6
COAD	RPL5 →	+0.177	+0.080	<.001	<.001	3	5
PDAC	BAZ1B →	+0.176	+0.051	<.001	.002	3	5
PDAC	TNS1 →	-0.246	-0.053	<.001	<.001	3	5
PDAC	EFEMP2 →	-0.518	-0.053	.004	.007	3	5
LUAD	MCM2 →	+0.515	+0.074	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031340 vs SYNPO_S685 — PDAC

Explore this scatter interactively →