Positive regulation of vesicle fusion

Across TCGA patient cohorts, RNA activity of the Positive regulation of vesicle fusion pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C6orf120, RNU6-33P, and OSTF1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of vesicle fusion activity versus C6orf120 in CCRCC (Pearson r = -0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	C6orf120 →	-0.240	-0.470	.007	.006	3	4
UCEC	RNU6-33P →	-1.030	-0.440	.004	.004	3	3
LUAD	OSTF1 →	+0.240	+0.530	.003	.001	3	3
UCEC	ADGRL3 →	-1.198	-0.513	.005	<.001	3	3
PDAC	MIR223HG →	+0.548	+0.594	.006	.001	3	3
COAD	HOXD9 →	-0.870	-0.605	.002	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031340 vs C6orf120 — CCRCC

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