Positive regulation of vesicle fusion

Across TCGA cell cohorts, RNA activity of the Positive regulation of vesicle fusion pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANXA1, PRXL2C, and FOSL1, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of vesicle fusion activity versus ANXA1 in BLOOD_Lymphoma (Pearson r = 0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	ANXA1 →	+4.847	+1.092	<.001	.001	3	11
BREAST	PRXL2C →	+0.904	+0.392	<.001	.003	3	7
BREAST	FOSL1 →	+4.015	+0.475	<.001	<.001	3	6
BLOOD_Leukemia	ANXA2 →	+2.399	+1.253	<.001	<.001	2	7
BLOOD_Lymphoma	PLAUR →	+1.672	+0.809	.006	.001	3	6
LARGE_INTESTINE	SLC25A37 →	+1.463	+0.353	<.001	.001	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031340 vs ANXA1 — BLOOD_Lymphoma

Explore this scatter interactively →