Positive regulation of protein-containing complex assembly

Across TCGA patient cohorts, RNA activity of the Positive regulation of protein-containing complex assembly pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are STAB1, PPM1F, and SEPTIN4_S432, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of protein-containing complex assembly activity versus STAB1 in GBM (Pearson r = 0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	STAB1 →	+0.368	+0.030	<.001	<.001	3	9
BRCA	PPM1F →	+0.287	+0.029	<.001	<.001	3	9
GBM	SEPTIN4_S432 →	+0.870	+0.034	<.001	<.001	3	8
COAD	BGN →	+0.886	+0.030	<.001	<.001	3	8
BRCA	CLIC2 →	+0.613	+0.027	<.001	<.001	3	8
GBM	CNRIP1 →	+0.578	+0.044	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031334 vs STAB1 — GBM

Explore this scatter interactively →