Positive regulation of protein-containing complex assembly

Across TCGA cell cohorts, RNA activity of the Positive regulation of protein-containing complex assembly pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are POLR3GL, THTPA, and PPP2CB, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of protein-containing complex assembly activity versus POLR3GL in LARGE_INTESTINE (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	POLR3GL →	+0.805	+0.159	<.001	.009	2	6
LUNG_SCLC	THTPA →	+0.826	+0.172	.007	.008	3	5
LUNG_SCLC	PPP2CB →	+0.985	+0.218	.001	.002	3	5
LUNG_SCLC	CDS1 →	-1.701	-0.164	.001	.002	3	5
LUNG_SCLC	NUDT2 →	+1.134	+0.178	.003	<.001	3	5
LUNG_SCLC	POLR3D →	+0.778	+0.147	.002	.008	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031334 vs POLR3GL — LARGE_INTESTINE

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